Nonapeptide-1 (Topical)

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This product is intended for research purposes only. To be used by trained professionals only.

Nonapeptide-1 topical is a short chain of nine amino acids linked together. It is a biomimetic peptide, which means it mimics natural molecules found in the body. Lab studies have shown it might reduce synthesis of melanin that’s the process that gives your skin its color. What’s got scientists excited is how it interacts with specific receptors on skin cells. [1]

Melanocytes are the cells that make melanin. They use a pathway that gets triggered by the MC1R receptor (melanocortin-1 receptor). When MSH hormone activates this receptor, it starts melanogenesis the melanin making process. But here’s the interesting part: research shows Nonapeptide-1 can interfere with this receptor and basically tell the skin to slow down pigment production. [2]

By blocking this early step, Nonapeptide-1 could help reduce melanin production. That’s why it’s such a promising candidate for research into hyperpigmentation, uneven skin tone, melasma, and similar concerns.

Potential Benefits of Nonapeptide-1 Topical

Studies are showing that Nonapeptide-1 topical might be valuable for researching pigmentation disorders and skincare applications. The main focus? How it reduces brown spots and dark patches. Research indicates it could help even out skin tone and improve overall complexion – and the good news is it doesn’t seem to damage healthy tissue or cause irritation.

The peptide has a two-part mechanism. First, it affects the receptor that starts melanin production. Second, it reduces tyrosinase activity that’s the enzyme your body needs to make melanin. Block this enzyme, and the whole process slows down, meaning less pigment gets produced. This dual approach probably explains why animal studies show skin brightening effects.

In one particular study, researchers applied Nonapeptide-1 to mouse skin for external use. The treated areas became noticeably lighter than untreated spots. [3] Using a melanin index for measurement, they found a significant drop in pigmentation. These findings suggest Nonapeptide-1 really can reduce melanin production and fade dark spots making it worth investigating for pigmentation disorders.

But the benefits might go beyond evening out skin tone. Some researchers are exploring how this peptide affects aging signs like fine lines, skin firmness, texture, and skin conditioning properties. The peptide may also help maintain moisture levels in the skin. Though it’s still early research, the results hint at potential uses in anti-aging and wrinkle treatments down the road.

Acne and redness are also on researchers’ radar. Since melanin and inflammation often go together, they’re wondering if Nonapeptide-1 topical could tackle both problems by improving blood flow and reducing inflammation.

Its targeted approach affecting melanin without disturbing nearby tissue could make it gentler than harsh brightening treatments. This makes it an interesting candidate for cosmetic formulations and skincare products.

There’s even research looking at melanoma applications. Some melanoma cells have lots of the same MC1R receptor that Nonapeptide-1 targets. Scientists want to know if this peptide could influence how these cancer cells behave. Of course, way more research is needed here. [4]

Remember though all these findings come from lab studies using animals or cell cultures. We can’t assume the same effects in humans. Nonapeptide-1 is still strictly a research compound.

How Should Nonapeptide-1 Topical Be Stored?

Storage matters if you want to keep Nonapeptide-1 topical stable and functional. The peptide’s solubility can be affected by improper storage conditions. Store the peptide in a cold, dry place preferably at -20°C until you’re ready to use it. Once you’ve reconstituted it, keep the solution refrigerated between 2°C and 8°C.

Always use sterile containers and protect it from light, which can degrade the peptide. Avoid freezing and thawing repeatedly. This damages the peptide and ruins your experiments. Instead, divide it into small portions so you only thaw what you need.

This peptide is for research purposes only. It isn’t approved for human or animal use only qualified professionals should handle it in controlled laboratory settings.

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References:

[1] Lisa AVE, Galtelli L, Vinci V, Veronesi A, Cozzaglio L, Cananzi FCM, Sicoli F, Klinger M. Adoption of a Newly Introduced Dermal Matrix: Preliminary Experience and Future Directions. Biomed Res Int. 2020 Oct 16;2020:3261318.

[2] Mohammed YH, Moghimi HR, Yousef SA, Chandrasekaran NC, Bibi CR, Sukumar SC, Grice JE, Sakran W, Roberts MS. Efficacy, Safety and Targets in Topical and Transdermal Active and Excipient Delivery. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. 2017 Jan 25:369–91.

[3] Huang ZJ, Zhou XH, Wen WQ, Huang ZT, Xuan J, Gui P, Peng W, Wang G. Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging. Int J Pharm. 2024 Nov 15;665:124690.

[4] Traversari C, van der Bruggen P, Luescher IF, Lurquin C, Chomez P, Van Pel A, De Plaen E, Amar-Costesec A, Boon T. A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E. J Exp Med. 1992 Nov 1;176(5):1453-7.

Molecular formula: C61H87N15O9S

Molecular weight: 1206.5

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Lithuania Direct Peptides website: https://lithuania.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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