Buy PT-141 Peptide Lithuania
PT-141, or Bremelanotide, is a synthetic peptide that stimulates melanocortin receptors in the brain to enhance sexual desire and function in both men and women. By targeting the brain’s sexual response circuits, it shows potential as a treatment for sexual dysfunction or low libido.
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PT-141 (Bremelanotide) Nasal Spray
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PT-141 Peptide Vial (Bremelanotide)
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PT-141 Pre-Mixed Pen 10mg Peptide
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What is PT-141?
PT-141 from Direct Peptides is a peptide designed to help with sexual dysfunction. It is also known as Bremelanotide and works by stimulating the central nervous system. This is different from other treatments like Viagra that work on the vascular system by improving blood flow. The peptide activates specific receptors called melanocortin receptors in the brain. Lithuania Studies have demonstrated that these receptors are linked to both sexual desire and arousal.
PT-141 was researched initially for tanning purposes and treating various skin conditions until its aphrodisiac effects were discovered. It has been approved for treating hypoactive sexual desire disorder (HSDD). It is FDA-approved for women but remains under study for broader applications.
This innovative solution is administered via subcutaneous injection or nasal spray and is still undergoing research to assess its effectiveness and safety for clinical use.
PT-141 Mechanism Of Action
PT-141 is a neuropeptide that works directly on the brain’s neural pathways linked to sexual response. Its mechanism of action differs from the usual ways of enhancing blood flow. It focuses on melanocortin receptors, especially the MC4R receptor found in the brain. By doing so, it influences the neurological signals that play a role in desire and arousal.
Activating this receptor triggers the hypothalamus, influencing both hormonal regulation and behavior. This sets off the HPG axis (hypothalamic-pituitary-gonadal), releasing neurotransmitters such as dopamine that substantially impact motivation and excitement.
As a result, it effectively boosts desire and performance without the cardiovascular adverse effects seen in other treatments. This innovative method shows promise in managing conditions like HSDD, offering a potentially significant advancement for sexual health care provision.
Source: PubChem
Structure of PT-141
Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.2 g/mol
PubChem CID: 9941379
What Are The Research Benefits of PT-141?
Novel Mode of Action: The mechanism of targeting the central nervous system rather than the vascular system offers a new avenue for understanding sexual arousal and desire, making it a pioneering subject in sexual dysfunction research.
Targeted Neurological Effects: PT-141 works by targeting melanocortin receptors, especially MC4R, allowing Lithuania researchers to study the neural pathways involved in sexual response. This could lead to important advancements in neurobiological research.
Reduced Cardiovascular Risks: Due to its central nervous system activity, PT-141 Lithuania potentially offers a safer profile compared to conventional treatments for sexual dysfunction that function via the vascular system. This reduction in cardiovascular involvement may lessen the risk of adverse events, such as haemorrhage, associated with increased blood flow or vascular stress.
Potential in Infection Research: Recent Lithuania studies suggest that melanocortin receptor agonists may help regulate the immune system by controlling inflammation and improving the body’s ability to fight infections. This shows promise in infection management.
Exploratory Research on Haemorrhage Risks: Researchers can utilise the peptide to investigate its effects on sexual arousal without the heightened risk of haemorrhage. This is particularly significant for populations that may be predisposed to vascular complications, allowing for safer therapeutic exploration and potential applications.
Potential in Oncology Research: Emerging Lithuania studies suggest it may have potential implications in oncology research. Its unique interaction with melanocortin receptors, particularly MC4R, opens new possibilities for exploring how these pathways may influence cancer cell behaviour and proliferation. By studying how it affects the cellular processes behind tumor growth and metastasis, researchers could discover new strategies for treating cancer.
Broad Therapeutic Potential: Its ability to directly influence sexual desire and arousal positions it as a versatile compound for investigating and potentially treating conditions like hypoactive sexual desire disorder (HSDD) in both men and women.
Enhanced Bioavailability: Research formulations of PT-141 Lithuania are optimised for maximum absorption and utilisation within the body, providing more reliable and consistent results in experimental settings.
Comprehensive Experimental Applications: It supports a wide range of research applications, from understanding fundamental sexual behaviour to developing potential therapeutic agents for sexual health disorders.
Supporting Advanced Studies: With its defined mechanism and targeted effects, it lays the groundwork for more advanced and specialised studies into the neurological and endocrinological aspects of sexual function.
Buy PT-141 for research online today!
Buy Kisspeptin and PT-141 Peptide Stack
Buy PT-141 Kisspeptin Peptide Stack, combining two peptides targeting sexual function and reproductive health. It enhances arousal, while Kisspeptin regulates hormones and fertility. Together, they provide a comprehensive tool for studying sexual dysfunction and hormonal pathways.
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Buy PT-141 Peptide Nasal Spray
Buy PT-141 nasal spray for a convenient, needle-free option in peptide research. With rapid absorption and quick action, it’s a valuable tool for researchers. Studied for its potential in sexual dysfunction and neuroendocrine research, it is a versatile and reliable choice.
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Frequently Asked Questions (FAQs) about PT-141
What is the regulatory status of PT-141?
Clinical trials have received regulatory approval in various regions to buy PT-141 for treating HSDD in premenopausal women. Approval includes the Food and Drug Administration (FDA) in the United States and the Medicines & Healthcare products Regulatory Agency (MHRA) in the UK. Continued research and development are expanding its potential applications and approval statuses globally.
Can PT-141 be used alongside other medications?
Bremelanotide may interact with other medications, so researchers must consult healthcare providers and assess potential interactions to ensure participant safety and study integrity.
How quickly does PT-141 work?
According to various reports, it typically starts taking effect within 30 minutes to an hour after you take it. While the length of its effectiveness can differ from person to person, it usually lasts for several hours, giving plenty of time for engaging in sexual activity.
Are there any side effects associated with PT-141?
Like any medication, Bremelanotide can cause potential side effects, with nausea, headache, irritation at the injection site, and flushing being the most commonly reported. However, it presents fewer cardiovascular risks, making it a potentially safer alternative to other sexual dysfunction therapies.
Are there any off-label uses for PT-141?
Research is ongoing into potential off-label uses, including its role in infection research and oncology. Although promising, these applications are still under study, and they should only be used as prescribed by a healthcare professional.
What makes PT-141 different from other treatments for sexual dysfunction?
Unlike other treatments that primarily act on the vascular system to achieve their effects, Bremelanotide targets the central nervous system. This unique mechanism may offer better efficacy for some individuals and a reduced risk of cardiovascular side effects.
Where is the best place to buy PT-141?
The best place to buy PT-141 with assured quality and high purity is from Direct Peptides Lithuania. We offer peptides with a guaranteed purity of 99%, making us the ideal choice for researchers seeking reliable and practical solutions.
Summary of Research Applications
- Treatment of HSDD in premenopausal women.
- Central Nervous System Activation targeting melanocortin receptors, particularly MC4R, for its effects.
- Research indicates potential benefits for male ED patients with similar erectile response issues.
- Reduced cardiovascular side effects compared to other sexual dysfunction therapies.
- Neuroendocrinological Studies support advanced research into the neurological and endocrinological aspects of sexual function.
- Ongoing research into broader applications, including infection research and oncology.
PT-141 Peptide Quality Assured
Buy PT-141 with 99% purity from Direct Peptides, designed to support your scientific studies on sexual health.
Our focus on purity ensures high-quality Bremelanotide, making it dependable for advanced research and innovative uses.
View the High-Performance Liquid Chromatography HPLC Certificate here.
References For Further Reading
[1] H.Wessells, V.J.Hruby, J.Hackett, et al (2003) Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors – Neuroscience, 2003;118(3):755-62
[2] R.C.Rosen, L.E.Diamond, D C Earle, et al (2004) Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra – International Journal of Impotence Research, 2004 Apr;16(2):135-42.
[3] M.R.Safarinejad and S.Y.Hosseini (2008) Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study – The Journal of Urology, 2008 Mar;179(3):1066-71.
[4] A.S.Rössler, J.G.Pfaus, H.K.Kia, et al (2006) The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat – Pharmacology, Biochemistry, and Behaviour, Volume 85, Issue 3, November 2006, Pages 514-521.
[5] P.B.Molinoff, A.M.Shadiack, D.Earle, L.E.Diamond, and C.Y.Quon (2006) PT-141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction – Annals of the New York Academy of Sciences, Volume 994, Issue 1, The Melanocortin System, June 2003, Pages 96-102.
[6] A.H.Clayton, S.E.Althof, S.Kingsberg, et al (2016) Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial – Womens Health (London), 2016 Jun; 12(3): 325–337.
[7] M.K.Miller, J.R.Smith, J.J.Norman, et al (2018) Expert opinion on existing and developing drugs to treat female sexual dysfunction – Expert Opinion on Emerging Drugs, 2018 Sep;23(3):223-230.
[8] C.Spana, R.Jordan, and S.Fischkoff (2022) Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials – Diabetes Obesity and Metabolism, 2022 Jun;24(6):1084-1093.
[9] M.Sandrock, A.Schulz, C.Merkwitz, et al (2009) Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice
– Reproductive Biology and Endocrinology, 2009; 7: 24.
[10] L.Feller, R.A.G.Khammissa, B.Kramer, et al (2016) Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face – Head Face Medicine, 2016 Feb 5:12:11
[11] V.Maresca, E.Flori, and M.Picardo (2015) Skin phototype: a new perspective – Pigment Cell and Melanoma Research, 2015 Jul;28(4):378-89.
Why Choose Direct Peptides Lithuania?
Buy PT-141 Lithuania today and experience unmatched quality with Direct Peptides, your premier source for Bremelanotide peptides. Setting us apart is our unique array of formulations, including peptide vials available in 10mg and a kit with bacteriostatic water and syringes. We also offer peptide nasal sprays available in 15ml and 30ml spray bottles, pre-mixed peptide pens, and even peptide stacks. Catering to varied research needs, we ensure that Lithuania researchers have access to the precise formulation required for their specific projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Lithuania Direct Peptides website: https://lithuania.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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This article explores PT141 as a possible treatment to enhance libido in premenopausal women by addressing both physical and psychological aspects of sexual desire. It highlights patient-reported improvements, a solid safety record, and few side effects.
What Is PT-141?
A brief look at PT-141 in comparison to other medications on the market, such as Viagra. It also discusses clinical trials with nasal sprays, which have shown promise. With more research, it could gain FDA approval to treat low libido and erectile dysfunction in men and women.